ColdZyme Mouth & Throat Spray (Not Nasal Spray) - Cold Virus Treatment & Symptom Relief - Use at First Signs of a Cold - Menthol Flavour 20ml

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The 9 item (items 12 to 20) QoL domain of the WURSS-21 was calculated by summing the individual scores recorded for the question “How much has your cold interfered with your ability to…”: Think clearly, sleep well, breathe easily, walk-climb stairs-exercise, accomplish daily activities, work outside the home, work inside the home, interact with others, and live your personal life [ 16]. Press down on the pump and spray 2 puffs (1 dose) every two hours up to 6 times daily while you are exposed to the cold virus.Out of the participants who reported absence of a cold in the previous week, 69% reported a positive answer to the question if ColdZyme had prevented them from catching a cold in the previous week. Jackson’s symptom scale and the 9-item Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) quality of life (QoL) domain and sore throat scale were recorded daily by subjects, as well as any use of allowed rescue treatment.

Results Between January and April 2019, 701 subjects were enrolled and randomly assigned to the ColdZyme group (n=351) or the placebo group (n=350). The product has a sickly sweet taste and does nothing for the throat, making it itchy and a bit paintful. If >3 days of cold were reported the previous week, reported days the following week were counted as belonging to the same incident. It was a prospective, multicenter, randomized, double-blind study to evaluate the efficacy of ColdZyme for common cold using a parallel-group design that compared the investigational device to placebo in subjects with naturally occurring common colds. The two-sided confirmatory null-hypothesis for the primary endpoint, the major secondary endpoints and continuous other secondary endpoints were analyzed for between-group comparison using the non-parametric two-sided Wilcoxon (Mann-Whitney U) rank-sum test, unstratified as well as stratified by study center (Van-Elteren or generalized Mann-Whitney test) to assess the treatment effect adjusted by the influence of sites.They mention that it really works, is natural, and is useful for this particular year when everyone you meet has a cold. Pregnancy or nursing, history of or current abuse of drugs, alcohol or medication, participation in the present study of a person living in the same household as the subject, inability to comply with study requirements according to investigator’s judgement or participation in another clinical study in the 30 days prior to enrolment and during the study, were also exclusion criteria. Lastly, the trypsin enzymes deactivate the virus particles preventing them from infecting cells, multiplying and spreading. The 103 third parties who use cookies on this service do so for their purposes of displaying and measuring personalized ads, generating audience insights, and developing and improving products. Adults experiencing a minimum of three common colds during the previous year, but otherwise healthy, were enrolled to begin treatment with the mouth spray or placebo six times daily at first sign of a common cold.

uk accepts no liability for inaccuracies or misstatements about products by manufacturers or other third parties. A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Study on ColdZyme® Mouth Spray against Rhinovirus-Induced Common Cold.

In addition, several safety endpoints were defined, including physical examination, vital signs and adverse events throughout the study, as well as global evaluation of tolerability by subjects and investigators at study end and assessment of device deficiencies at Visit 2 and Visit 3. The beneficial effect of ColdZyme was particularly noticeable on the fifth day of the common cold, often the pivotal day to restoring wellness. It must not be used after the expiry date, which is printed on the label of the bottle and on the bottom of the package.

in both groups) of the subjects used concomitant treatment that might affect common cold symptoms on all four days. An ordinary cold usually lasts for fewer than ten days and, on average, people have two to five colds per year. The barrier deactivates airborne viruses at the back of the throat - stopping them from sticking to cells and causing infection.Further, 10% fewer subjects reported WURSS-21 QoL scores greater than zero in the ColdZyme group (p = 0. Individual participant data, after having been anonymized, will be made available, along with the study protocol, statistical analysis plan and informed consent form template. The full analysis set (FAS) was defined in the statistical analysis plan (SAP), prior to unblinding and statistical analysis, as all subjects of the all subjects treated set (AST, n = 438) for which at least one of the confirmatory endpoints could be evaluated. A positive difference between treatment groups was also seen for the subjects’ assessments of global efficacy of the investigational product A robust safety profile for ColdZyme was demonstrated throughout the study.